Hwang adapted the play for a 1993 film directed by David Cronenberg with Jeremy Irons and John Lone in the leading roles. 
The widespread consumption of evening primrose oil as a supplement and the availability of clinical data make data from animal studies largely irrelevant.
As mentioned above, important differences exist in nearly all respects between the human and rabbit appendixes ( Dasso et al. 2000 ; Williams and Myers 1994 , p. 57). The rabbit appendix, for instance, is very difficult to identify as separate from the rest of its voluminous caecum (see Figure 2 ). Unlike the human appendix, the rabbit's appendix is extremely large, relative to the colon, and is the seat of extensive cellulose degradation due to a specialized microflora. The large rabbit appendix houses half of its GALT lymphoid tissue, whereas the contribution of the human appendix to GALT is significantly less ( Dasso et al. 2000 ). In humans the vast majority of GALT tissue is found in hundreds of Peyer's patches coating the small intestine and in nearly 10,000 similar patches found in the large intestine. Additionally, there are important differences in lymphoid follicular structure, in T-cell distribution, and in immunoglobulin density ( Dasso et al. 2000 ). Furthermore, from systematic analysis we know that the rabbit, rodent, and human appendixes are convergent as outgrowths and constrictions of the caecum ( Shoshani and McKenna 1998 ). It is thus very questionable to conclude from these animal studies that the human appendix has the same function as the other non-primate appendixes.
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